Introduction: The inflammatory response is essential to initiate the healing\nprocess, and in this response there is an increase in white blood cells and\npro-inflammatory compounds. C reactive proteins (CRP), together with the\nblood leukocyte count, have been used to study the immune response. Due to\nthe risk of infection and exacerbated inflammatory response of the patients\nundergoing surgical procedure, it is relevant to investigate the pre and postoperative\ninflammatory response of those individuals. Objective: To determine\nthe difference in the impact of elective cholecystectomy surgery on the\npatientâ??s immune response. Methods: The present study was cross-sectional,\nwhere a group included patients who underwent elective cholecystectomy\nprocedure. Patients who were pregnant, under 18 years, of indigenous communities\nor with other conditions that depress the immune system, as well as\nthose on immunosuppressive medications, were excluded. Results: CRP and\nleukocyte counts indicated a mean increase of 5.97-fold (95% CI 3.76 to 8.34,\nSD 6.98) and 1.97-fold (95% CI 1.71 to 2.24, SD 1.97) respectively, both being\nevaluated before and after surgery. Discussion: In the present study, to avoid\na possible methodological bias, it was chosen to evaluate the patients submitted\nto video laparoscopic cholecystectomy only and the hypothesis was confirmed\nthat there is an increase in CRP and leukocyte count as a response to\nsurgical trauma. Conclusion: There was an elevation of the inflammatory\nmarkers in patients submitted to surgical trauma when comparing the exams\ncollected in the preoperative period and after the surgical aggression.
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